Purification of triamcinolone acetonide suspension for intravitreal injection
نویسندگان
چکیده
منابع مشابه
Preservative-free triamcinolone acetonide suspension developed for intravitreal injection.
OBJECTIVES All commercially available triamcinolone acetonide (TACA) suspensions, used for intravitreal treatment, contain retinal toxic vehicles (e.g., benzyl alcohol, solubilizer). Our aim was to find a convenient and reproducible method to compound a completely preservative-free TACA suspension, adapted to the intraocular physiology, with consistent quality (i.e., proven sterility and stabil...
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The introduction of pars plana vitrectomy in clinical ophthalmology by Robert Machemer and colleagues was a profound paradigm change which opened up new avenues for the treatment of ocular diseases, such as proliferative vitreoretinopathy, which up to that time had been incurable [79]. It was again Robert Machemer who together with Yasuo Tano, Gholam Peyman, Stephan Ryan and other researchers f...
متن کاملComparison of different techniques for purification of triamcinolone acetonide suspension for intravitreal use.
BACKGROUND Intravitreal triamcinolone has increasingly been used for the treatment of oedematous and neovascular diseases and purification of triamcinolone suspension may be important in order to avoid the potential toxic effects of the vehicle. The aim was to evaluate different techniques used to reduce the solvent agent benzyl alcohol (9.9 mg/ml) from a commercially prepared triamcinolone ace...
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Chronic intraocular inflammation such as chronic uveitis can lead to cystoid macular oedema, papilloedema, and vitreous opacities temporarily or permanently reducing visual acuity. Chronic uveitis has usually been treated by topical or systemic application of steroids. Topical treatment, however, often has not been sufficiently effective to suppress intraocular inflammation and to reduce cystoi...
متن کاملIntravitreal injection of triamcinolone acetonide as treatment for chronic uveitis
Chronic intraocular inflammation such as chronic uveitis can lead to cystoid macular oedema, papilloedema, and vitreous opacities temporarily or permanently reducing visual acuity. Chronic uveitis has usually been treated by topical or systemic application of steroids. Topical treatment, however, often has not been sufficiently effective to suppress intraocular inflammation and to reduce cystoi...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2006
ISSN: 0007-1161
DOI: 10.1136/bjo.2005.083501